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Herpesviruses can be used as vectors for gene delivery into mammalian cells. One of the advantages of the poxvirus system for gene delivery is the ability of this virus to transfect non-dividing cells, which is mainly based on the capacity of the vaccinia virus to enter cells in an early phase of infection. Infection of human tumors with vaccinia virus expressing the herpes simplex virus-thymidine kinase gene (vHSV-tk) followed by treatment with ganciclovir leads to specific growth inhibition of human tumor cells expressing the HSV-tk gene. This strategy is also applicable to other types of human tumors, which have been shown to be susceptible to vHSV-tk. In addition, the use of high doses of ganciclovir in combination with IL-2 or IL-2 variants will render tumor cells more sensitive for a further therapy with the ganciclovir-HSV-tk-system. The major drawbacks of this system are the necessity of treating the patient for months with a potent cytostatic and the induction of resistance after prolonged application of ganciclovir. Recently, the combination of the herpes simplex virus thymidine kinase gene with interleukin-2, which is directed at the induction of the immune system against tumor cells, resulted in strong synergistic effects. In addition, it was shown that vaccinia virus can be used for the transfer of other transgen 0b46394aab